Tretinoin cream is one of the most widely used topical preparations in the world. It is prescribing by the dermatologists for a variety of skin conditions such as acne, photo damaged skin, wrinkling. It has studied most for its use as an anti-acne medication.
Being a vitamin A derivative, Tretinoin got excellent effect on controlling epithelial cell proliferation and differentiation. These two processes are vital for normal skin. When abnormalities arise from these processes then various skin disorders appear. By normalizing cell proliferation and differentiation, Tretinoin effectively treats these conditions.
Various strengths of Tretinoin cream are available. Most commonly used strengths are 0.025%, 0.05% and 0.1%. Different strengths of this preparation have been developed for diversified topical use and due to its irritation potential. Higher strength Tretinoin cream ensures greater activity. But it may cause greater irritation. Initial irritation disappears with use and during transition period user does not feel such skin discomfort. So for user compliance it is commonly advised to use at evening or at night time. If used in day time or where sun exposure can not be avoided then sunscreen or protective clothing are recommended.
Tretinoin 0.025% cream is widely used for the topical treatment of comedonal acne. Comedone appears due to obstruction of sebaceous glands by keratin. Due to abnormal epithelial cell differentiation, excessive keratin is accumulated. Tretinoin 0.025% cream effectively controls this situation and brings the comedone at skin surface. As a result sebaceous glands become free and the comedone disappears. Application frequency is once daily. Other than acne vulgaris Tretinoin 0.025% is also used in aging skin affected by wrinkles.
Tretinoin cream at strength of 0.05% is popular in use for treating skin conditions like wrinkling and rough facial skin. It has excellent effect in reducing fine wrinkling in aging skin. It helps in generating new cells and removes the dead cell from the skin surface. Once daily dose is effective in eradicating outer layer dead cells and makes the skin smooth. It is also prescribed by the dermatologists as an adjunctive therapy with topical Minoxidil to regrow hair. When used with Minoxidil, it shows greater effect in new hair growth than Minoxidil alone.
Depending on skin conditions and patient’s tolerability dermatologists prescribe Tretinoin 0.1% cream for acne vulgaris, wrinkling and photo damaged skin. Usually this higher strength is suggested when the patient develops tolerability with Tretinoin. Patient needs to be more careful when using this strength for example has to avoid sunlight.
Excessive ultra violet radiation exposure causes great damage to the human skin. As a result skin cell becomes dead; cell surface turns rough and ultimately causes premature skin aging. Tretinoin cream exerts excellent effect in these conditions. It increases new skin cell growth and removes damaged skin cells. It is a proved weapon for dermatologists to treat photo damaged skin where it can be used alone or in combination with other agents. Currently most of the renowned anti-wrinkling or anti-aging formulation contains Tretinoin as one of the major active ingredients.
During application of Tretinoin cream skin dryness occurs. Especially this condition worsens with user who is already suffering from dry skin. So it is recommended to use skin moisturizer before, after or at the same time of applying this medication. Agents that cause skin dryness like soap, rough skin cleanser have to avoid or have to use carefully during application of Tretinoin cream.
There are some common side effects associated with the application of Tretinoin cream like burning or irritation at the site of application, dry skin, etc. These conditions are usually mild to moderate in nature and declines with time.
Diversified use of Tretinoin cream in various skin disorders and due to excellent efficacy, its use is emerging in skin care treatment.
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